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        技術文章您現在的位置:首頁 > 技術文章 > Emfret公司血小板消除抗體R300說明書

        Emfret公司血小板消除抗體R300說明書

        更新時間:2024-01-23   點擊次數:1019次

        Emfret公司血小板消除抗體R300說明書

        Antibodies for Platelet Depletion in Mice

        638416058038679696435.jpg


        # R300




        產品資料


        貨號

        R300

        同種型(isotype)

        大鼠IgG (Wistar)

        含量

        0.5 mg purified immunoglobulins in PBS, sterile filtered

        包裝

        1ML

        濃度

        0.5 mg/ml

        本產品只用于科研,不用于診斷,也不屬于醫療用品

        638416043231158960774.jpg

        特異性: This antibody preparation contains a mixture of purified rat monoclonal antibodies  directed

        against mouse GPIba (CD42b). Targeting of this receptor with divalent IgGs results in profound and

        irreversible Fc-independent plaet depletion in mice1,2. Plaet depletion is frequently used to study

        the general role of plaets in (patho-) physiology3.


        制備 : 抗體是雜交瘤細胞上清通過G-Sepharose純化所得,內毒素含量小于 0.0025 EU/µg


        保存和運輸:4度保存和運輸,保質期為6個月 ,無菌保存不含防腐劑,分裝保存-20度至少可以保存一年以上,但請避免反復凍融


        使用方法: 按動物體重注射抗體,用 量為2 µg抗體/g動物體重,可以參見上圖。如果4 µg抗體/g動物體重,可以持續更長時間。注射后60分鐘內可以去除血小板95%以上,建議每次注射100-200µL抗體(用無菌PBS稀釋)。詳情聯系靶點科技技術支持??梢月摵锨宄奘杉毎↙IPOSOMA,CP-005-005)和中性粒細胞,咨詢綜合解決方案。




        引用文獻:

        1. Bergmeier W, Rackebrandt K, Schroder W, Zirngibl H, Nieswandt B. (2000) Structural and functional characterization of the mouse von Willebrand

        factor receptor GPIb-IX with novel monoclonal antibodies. Blood. 95:886-93.

        2. Nieswandt B, Bergmeier W, Rackebrandt K, Gessner JE, and Zirngibl H. (2000) Identification of critical antigen-specific mechanisms in the

        development of immune thrombocytopenic purpura in mice. Blood. 96:2520-27.

        3. Elzey BD, Tian J, Jensen RJ et al. (2003) Plaet-mediated modulation of adaptive immunity. A communication link between innate and adaptive

        immune compartments. Immunity.19:9-19.



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